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4-PPBP maleate
CAS No. 201216-39-9
4-PPBP maleate( —— )
Catalog No. M33824 CAS No. 201216-39-9
4-PPBP maleate is a potent σ1 receptor (ligand) agonist and a selective, non-competitive NR1a/2B NMDA receptor antagonist in the context of Xenopus oocytes expression, with neuroprotective properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 65 | Get Quote |
|
| 10MG | 107 | Get Quote |
|
| 25MG | 210 | Get Quote |
|
| 50MG | 339 | Get Quote |
|
| 100MG | 494 | Get Quote |
|
| 500MG | 1053 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product Name4-PPBP maleate
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NoteResearch use only, not for human use.
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Brief Description4-PPBP maleate is a potent σ1 receptor (ligand) agonist and a selective, non-competitive NR1a/2B NMDA receptor antagonist in the context of Xenopus oocytes expression, with neuroprotective properties.
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Description4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection.
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In Vitro4-PPBP maleate elicits ERK1/2 phosphorylation in primary neurons.
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In Vivo4-PPBP maleate (1 μmol/kg; i.v.) decreases brain injury after transient focal ischemia in rats.Animal Model:Male rats weighing 300 to 385 g (Transient focal ischemia model)Dosage:1 μmol/kg Administration:Per hour by continuous intravenous infusion starting 1 hour after the initiation of ischemia and continuing through 22 hours of reperfusion.Result:Decreased brain injury after transient focal ischemia in rats.
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Synonyms——
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PathwayAutophagy
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TargetSigma receptor
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RecptorSigma receptor | NMDAR
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Research Area——
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Indication——
Chemical Information
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CAS Number201216-39-9
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Formula Weight409.52
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Molecular FormulaC25H31NO4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (610.47 mM; Ultrasonic )
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SMILESC(=C\C(O)=O)\C(O)=O.C(CCCC1=CC=CC=C1)N2CCC(CC2)C3=CC=CC=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Whittemore ER, et al. Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition. J Pharmacol Exp Ther. 1997;282(1):326-338.?
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