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4-PPBP maleate

CAS No. 201216-39-9

4-PPBP maleate( —— )

Catalog No. M33824 CAS No. 201216-39-9

4-PPBP maleate is a potent σ1 receptor (ligand) agonist and a selective, non-competitive NR1a/2B NMDA receptor antagonist in the context of Xenopus oocytes expression, with neuroprotective properties.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    4-PPBP maleate
  • Note
    Research use only, not for human use.
  • Brief Description
    4-PPBP maleate is a potent σ1 receptor (ligand) agonist and a selective, non-competitive NR1a/2B NMDA receptor antagonist in the context of Xenopus oocytes expression, with neuroprotective properties.
  • Description
    4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection.
  • In Vitro
    4-PPBP maleate elicits ERK1/2 phosphorylation in primary neurons.
  • In Vivo
    4-PPBP maleate (1 μmol/kg; i.v.) decreases brain injury after transient focal ischemia in rats.Animal Model:Male rats weighing 300 to 385 g (Transient focal ischemia model)Dosage:1 μmol/kg Administration:Per hour by continuous intravenous infusion starting 1 hour after the initiation of ischemia and continuing through 22 hours of reperfusion.Result:Decreased brain injury after transient focal ischemia in rats.
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Sigma receptor
  • Recptor
    Sigma receptor | NMDAR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    201216-39-9
  • Formula Weight
    409.52
  • Molecular Formula
    C25H31NO4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (610.47 mM; Ultrasonic )
  • SMILES
    C(=C\C(O)=O)\C(O)=O.C(CCCC1=CC=CC=C1)N2CCC(CC2)C3=CC=CC=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Whittemore ER, et al. Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition. J Pharmacol Exp Ther. 1997;282(1):326-338.?
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